Boundary information of saline lake water was extracted,and combined with the field investigation and indoor interpretation analysis,with RS and GIS technology based on the remote sensing image data of five periods of Landsat in 1972 ~ 2013,the variation diagram of the changes of Saline Lake area during the five periods were drawn. In addition,the response relationship of saline lake area combined with the meteorological (precipitation,average temperature,relative humidity,average wind speed) of Kumukule Basin was analyzed,to explore the correlation between saline lake and climate change,and discuss the influence mechanism of climate change on the saline lake area,analysis on the effect of different meteorological factors on the area change of saline lake basin. The results show that:the average temperature, precipitation and relative humidity can promote the saline lake area broadening on the basin,and the role of average temperature is dominant. The results provide reference for the evolution of saline lake and saline lake resources exploration in Kumukule Basin.