Pressure of domestic water is aggravated by rapid urbanization and climate change,especially in Yunnan Province,where is prone to drought hazard. Based on the definition of vulnerability,this paper proposed a conceptual framework for vulnerability assessment of domestic water under drought stress and established an index system,in order to quantitatively describe the vulnerability in 2000 and 2010. The results show that,1) the most vulnerable regions are mostly located in central and western Yunnan; 2) DWVI in 2010 becomes more equal; 3) evolution patterns differ in different regions,that is,northern and central Yunnan show more vulnerable,while vulnerable regions in southwestern and northwestern Yunnan shrink. The suggestions put forward for further hazard governance are,to enhance supervision of vulnerable hot zones and to improve the adaptive capacity (e. g. make better domestic water plan etc. ).