Severe flooding disasters caused by extreme precipitation events have attracted more and more attention, while the relationship between climate change and extreme precipitation as well as flooding events has become the hottest scientific frontier issue. Flooding disasters in China by heavy rainfall occurred frequently in recent years under the background of global climate change,which has caused terrible harm on economic and social development, life security,ecosystem,etc.,brought profound impact on sustainable development of disaster area; become a key factor of global & regional disasters and environmental risk; and been widely concerned by academic circle and all sectors of the society. It should be noticed that the spatial-temporal pattern and change of decadal flooding caused by heavy rainfall in China neither have consistency with temperature rising,nor can be explained reasonably with atmospheric and oceanic climate factors. Here we use climate change regionalization (1961-2010) featured by precipitation tendency and fluctuation to calculate flooding frequency from 1961 to 2010. The result showed that: ①flooding frequency obvious increased both in warm-dry trend zone (WDTZ) and warm-wet trend zone (WWTZ). ②In WDTZ,the flooding frequency in precipitation fluctuation decreasing regions (1 612 times) was two times more than that increasing regions (818 times). ③While in WWTZ,the flooding frequency in precipitation fluctuation decreasing regions (512 times) was one-third of that increasing regions (1 377 times). Heavy rainfall demonstrated the similar spatial-temporal pattern. The results suggested,for the first time to our knowledge,that the dynamic changes of the climate may be the main influencing factors of regional flood difference. Our findings indicate that local anthropogenic processes may shift the regional climate beyond through GHG emissions. Rapidly growing and industrializing cities and nations will need to better control the air pollution,and to anticipate and accommodate these regional climate consequences,if they are to reduce the risk of flooding and waterlogging.