The experiment was conducted to study the response differences of radial growth of Picea schrenkiana to climate warming in Wusu and Shihezi regions. Dendrochronological methods including response function and evolutionary intervals analysis method were applied to study the relationships between radial growth and climatic factors of P. schrenkiana at the lower forest border of the two regions. The radial growth of P. schrenkiana at two regions was significantly correlated to the local climatic factors in the growing season, but the differences in response were statistically significant. In Wusu,the radial growth of P. schrenkiana was significantly negatively correlated to the average temperature in previous July and September but significantly positively correlated to precipitation in current August, the average relative humidity in previous September and current August, and scPDSI from July to October last year. In Shihezi,the radial growth of P. schrenkiana was significantly positively correlated to the average relative humidity in current January,and scPDSI in current January and February. The tree ring width index in Wusu showed a decreasing trend namely " separation phenomenon" with the increasing of temperature, while that in Shihezi was increased with the increasing temperature. For P. schrenkiana in Wusu, water stress caused by temperature rising was the main factor causing the opposite tendency between radial growth and temperature change. The increase of temperature and precipitation in the growing season mutually enhanced the P. schrenkiana growth in Shihezi. The sensitivity of radial growth of P. schrenkiana to average temperature and precipitation from May to July was increasing in Wusu. The sensitivity of radial growth of P. schrenkiana to precipitation from May to July was increased in Shihezi, while the sensitivity to average temperature was decreased from May to July. Therefore, the regional differences in climate change were the main factor in the radial growth difference at two regions and the sensitivity change to temperature and precipitation in chronological series.