The effects of the wing shape parameters and the flight conditions on the noises during approach, on the emissions during landing and takeoff (LTO)cycle, the total emitted greenhouse gas, the direct operating cost and the endurance were presented. The multiple perspectives of the environmental impact, airline operations and passenger experience were analyzed based on the multidisciplinary analysis framework. The analysis results indicate that the flap with fewer gaps may contribute to the noise reduction; meanwhile, a larger wing area is needed to compensate for the loss of aerodynamic effects. Reducing the cruise altitude may result in a decrease of the global warming impact but the increases of direct operating costs(DOC)and endurance. The steeper approach may reduce both of the noises during approach and the emissions during LTO. Considering economy and environmental impacts, two typical configurations of aircraft with the corresponding flight conditions are achieved after multi-objective optimization.