In 2007, a drinking water crisis breaking out in Wuxi City shocked the world while the eutrophication and harmful cyanobacterial blooms of Lake Taihu became an urgent problem to the public society. Also a higher request to the research of the emergency disposal and scientific explanation of the cyanobacterial blooms, and the water environment management and ecological restoration of Lake Taihu in the next decade. Taihu Laboratory for Lake Ecosystem Research, Chinese Academy of Sciences (hereinafter referred to as the TLLER) has carried on the comprehensive, long-term monitoring to Lake Taihu along with the research on shallow lake system evolution, technology development and engineering demonstration in order to aiming the aforementioned national science and technology needs since its establishment. Funded by national and ministerial projects, series of multi-disciplinary researches have been conducted supporting by the TLLER fieldwork platform and obtained remarkable progresses in the last 10 years. An novel in-situ approach integrating physical, chemical and biological disciplines was created, thus, explored a new situation for the studies combining modern processes and patterns of lake environmental elements with the structure and function of lake ecosystems. Moreover, the synergistic driving effect of human activity and climate change on lake's key ecological process was revealed, as well as the characteristics, regional differences and responding mechanism of the lake ecosystem caused by environmental changes; further, the driving effect of environment on ecosystems degradation was elucidated. Especially, technical approaches and management strategies for entrophic lake governance and ecological restoration were proposed and made significant achievements applying in Lake Taihu. These achievements filled the knowledge gap of large shallow lake that leading to a new frontier of international limnology research, and meanwhile, made the TLLER an irreplaceable fieldwork supporting platform and international well-known research base of lake science.