Based on the 1961 ~2015 meteorological data from Yinchuan of Ningxia autonomous region,this paper analyzed the change characteristics of the agricultural climate resources and agricultural climate factors that influenced on the quality of wine grapes and agro-meteorological disaster during the growth period of wine grape. The results revealed that the initial data of the average daily temperature over 10℃ showed a slight forward tendency and the closing time of the average daily temperature over 10℃ showed a significant delay tendency, ≥ 10℃ thermal time and the duration of the average daily temperature over 10℃ showed a significant increase trend, with the increment 97. 6℃ and 2. 6d per 10 years. The suitable unearthed time showed a slight forward tendency during the past 55 years in Yinchuan. The growing season and heat resources during growing season of wine grape showed a significant increase trend. Sunshine time showed a high decrease trend during growing season of wine grape, precipitation and diurnal temperature range showed a slight decrease trend during growing season of wine grape. The average temperature in last July to August increased 0. 28℃ per 10 years, which was harmful for forming excellent quality. The precipitation and precipitation days during September showed an increase trend that was not good for forming excellent quality. The frequency of different levels frost and injury winter freeze injury showed an increase trend.