The fragile ecosystems and human engineering activities in the Tibetan Plateau aggravate the desertification along the linear engineering of Qinghai-Tibet Engineering Corridor. Therefore block-stone embankment in permafrost regions faces increasing severe aeolian sand hazard. In this paper,cooling performance and long-time thermal stability of block-stone embankment with high-grade pavement under the scenario of aeolian sand were analyzed. The results showed that permafrost temperature is more easy to be affected by accumulation of aeolian sand for closed block-stone embankment by comparing the permafrost table under the center of permafrost embankment. Wet sand of 1.0 m depth can reduce permafrost temperature,while dry sand of 0.2 m depth can rise permafrost temperature. Permafrost temperature is more sensitive to water content of sand as compared with the sand deposit depth. Under the circumstance of climate warming,the impact of sand deposit on permafrost table of embankment will weaken with the mean annual air temperature decreasing. The dry sand increases the thawed depth of permafrost,and the wet sand raises permafrost table. Permafrost table beneath the center of embankment is more sensitive and the impact of accumulation of sand weakens together with the decrease of ice content of permafrost. When the mean annual air temperature is lower than - 5.5 ℃,closed block-stone embankment for high-grade highway could keep artificial permafrost table within the rock layer in the condition of climate warming and aeolian sand deposit.