Climate change is one of the main environmental factors with the potential to influence the productivity of Leymus chinensis.In this paper,potted plants were used to study the effects of brassinolide(BR)and nitrogen, phosphorus and potassium(N,P,K)on the growth and drought resistance of L.chinensis under normal(soil water content 80%of field capacity)and drought(soil water content 50% of field capacity)conditions. The results showed that appropriate BR concentration could alleviate plant injury under drought stress while the combination of BR and N,P,K (1% urea+1% potassium dihydrogen phosphate+0.10 mg·L~(-1) BR)could promote plant growth and nutrient accumulation,further improving drought resistance in L.chinensis.This was closely related to key physiological characteristics including regulation of plant growth,enhanced osmotic adjustment,reduced membrane lipid peroxidation and enhanced antioxidant enzyme activity.Plant height,fresh weight,dry weight and root vigour increased by 28.96%,62.46%,45.21%and 19.08%in the BR treated plants and with N,P,K by 20.74%,236.84%and 42.31%respectively compared with the CK. The activities of nitrate reductase(NR),acid phosphatase(ACP)and malate dehydrogenase(MD)changed with proline content;soluble protein and soluble sugar increased by 57.20%,22.82%and 5.94%respectively. Malondialdehyde conductivity and leaf permeability were reduced by 37.42%and 55.79%respectively,while superoxide dismutase(SOD),peroxidase(POD),catalase(CAT),glutathione reductase(GR)and ascorbate peroxidase(APX)activity increased(158.40%,38.15%,32.97%,30.00%and 28.74%respectively).