Based on the temperature and precipitation data from 191 meteorological stations in northwest China during the period from 1961 to 2014,many methods, such as the linear trend, running means,accumulative anomaly and IDW,were used to study the spatiotemporal variation of temperature and precipitation in northwest China. The results showed that the average temperature was in an increase trend,especially in winter. The trend of extreme maximum temperature and extreme minimum temperature was similar to that of average temperature. Precipitation was also in an increase trend,especially in recent years. Precipitation occurred mainly in summer, in particular, the precipitation in winter increased sharply since the 21st century. The high annual temperature occurred mainly in south Xinjiang and the southeast Qilian Mountains,especially in the Junggar Basin and the southwest Tianshan Mountains. Precipitation decreased gradually from the east to the west. More precipitation occurred in the southeast Qilian Mountains,and its low value occurred in south Xinjiang. Precipitation increase was significant in the west Tarim Basin and north Xinjiang. Viewing from the spatiotemporal variation of temperature and precipitation, there was a warming-wetting trend in northwest China.