Based on daily meteorological data of 104 meteorological stations in 4 ~ 9 months from 1958-2015 years in the eastern Yunnan-Guizhou Plateau,using accumulated temperature dryness index as drought index,the temporal and spatial distribution characteristics of flood season dry wet change trend and their relationship with climate factors were studied. The mutation characteristics of precipitation and temperature drying index were analyzed by Mann-Kendall mutation test method. Mexico hat wavelet transform is used to analysis dry and wet conditions of flood season dry wet in the eastern Yunnan-Guizhou Plateau. The result shows that the precipitation is generally between 800~1 000 mm on flood seasons in the eastern Yunnan-Guizhou Plateau,presenting the spatial distribution characteristics in the decline from south to North. Meanwhile,the standard deviation and the average precipitation are found to be uniform distribution. In recent 60 years,the average accumulated temperature dryness index on flood season in eastern Yunnan-Guizhou Plateau shows an increasing trend,but it has the alternation tendency between dry stage and wet stage. And the climate characteristic is developing towards the partial humidity direction. The spatial distribution of the accumulated temperature drying index is reverse phase of precipitation and its large /small value center is basically the same as that of the small /large. There is a significant correlation (P<0.01) between the accumulated temperature dryness and the average temperature,maximum temperature, sunshine duration,evaporation,precipitation and relative humidity. There is a significant correlation between the accumulated temperature dryness in the eastern Yunnan-Guizhou Plateau and the meteorological factors in the flood season,which indicates that the dry and wet climate changes are affected by several meteorological factors, and the single meteorological factors are difficult to reflect the changes of dry and wet conditions of the climate. The main reason for the drought in the eastern part of the Yunnan-Guizhou Plateau is the decrease of precipitation, followed by the increase of temperature. The index classification standard used in this study is truly and objective to reflect the degree of drought,and the calculation is simple. It only needs daily mean temperature and daily precipitation data. It can be calculated in a short period or in real time,which is beneficial to large scale application. Based on the above analysis,it is considered that the future climate in the eastern part of the Yunnan-Guizhou Plateau in the rainy season is developing towards a partial wet trend. Because of the complicated geological and geomorphologic conditions in the eastern part of Yunnan-Guizhou Plateau,there are certain limitations in judging the dry and wet climate change by two factors,temperature and precipitation. The complexity of drought formation still needs further study.