Regional climate differentiation is becoming more and more obvious with global climate change,regional climate tends to be extreme. Droughts,heavy rainfall,heat waves,snow,super typhoons and other extreme weather events that have brought huge losses all over the world every year are very frequent across the global. Research on small-scale regional climate using the global climate models can't meet the requirements of spatial scale,temporal scale,the regional scale assessment of climate change and adaptation research. The global climate model reproduce climatic characteristics from large scale and it can't finely show the local information at different elevations. A full understanding of the inter-regional climate differences is very important for a more accurate prediction of future climate change. As the regional climate models have a more complete physical mechanism and higher spatial resolution,it has made a great deal of improvement over the global climate model and can solve the problem the global climate model faced and has been widely used in regional climate research,notable results have been achieved. In this paper,we sketched the development of the regional climate model,summarized the latest research progress in the regional climate model,the world's major regional climate models, and the development of climate scenarios. And we also summarized the general trend of climate change in different regions of the world from temperature and precipitation,research findings in different regions can help to have a better understanding of future climate change and also can help policymakers develop appropriate applicability strategies that will reduce the loss caused by climate change. Although the models used by the researchers may be different,the precipitation estimates are not the same,and there are significant regional characteristics in different region,almost all studies agree that in the future the world will continue to experience a process of sustained warming. Based on a summary of future climate change in different regions,then we discussed the current problems of the regional climate model,including the uncertainty of the model itself,the uncertainty of emissions scenarios and the complexity of the earth-atmosphere system. Finally,for the problems in the regional climate model,we summarized the solutions in term of current regional climate models,and looked forward to the development of the regional climate model and give the trend of the future regional climate model in China.