Recently,researchers have made great effort to accelerate the progress of substitution for chlorodifuoromethane(HCFC-22)in order to tackle climate change so that refrigerant is undergoing significant change.In this work,we review the development history of refrigerant and introduce the present situation and development trend of alternative refrigerant for aiming at the substitution of HCFC-22.The present alternative refrigerants are analyzed in two aspect of safety performance and refrigeration capability.