Manure and supplementary irrigation application are proposed to increase the crop yield in semi-arid and semi-humid region of Loess Plateau, but the effects of manure and supplementary irrigation application on the greenhouse gas emission are not clear. In this study,CO_2,N_2O and CH_4 emissions were monitored by static-chamber gas chromatography technique,and global warming potential (GWP) and greenhouse gas intensity (GHGI) were then calculated. The experiment included three treatments (N: urea nitrogen fertilizer 180 kg·hm~(-2),NM: urea nitrogen fertilizer 180 kg·hm~(-2)+ manure 45*10~3 kg·hm~(-2),NMW: urea nitrogen fertilizer 180 kg·hm~(-2)+ manure 45*10~3 kg·hm~(-2)+ supplementary irrigation in wheat jointing stage). The results showed that: ① The fluxes of CO_2 emission increased with the growth process and decreased at the beginning of maturity. Compared with the N treatment,the cumulative CO_2 emissions of NM and NMW treatments were increased by 22.8% and 31.0%,arrived at 14933.35 kg·hm~(-2) and 15929.74 kg·hm~(-2),respectively. The fluxes of N_2O emission were suddenly increased after fertilization,rainfall and irrigation during winter wheat growing season. Compared with the N treatment,the cumulative N_2O emissions of NM and NMW were decreased by 23.8% and 17.5%,arrived at 0.48 kg·hm~(-2) and 0.52 kg·hm~(-2),respectively. The cumulative CH_4 absorption were 1.73 kg·hm~(-2) in NM treatment and 1.87 kg·hm~(-2) in NMW treatment,and decreased by 18.4% and 11.8% compared with N treatment,respectively. ② The CH_4 absorption rate was positive correlation with soil temperature and negative correlation with soil moisture content. The CO_2 and N_2O emission rate were positive correlation with soil temperature and soil moisture content. N_2O emission rate was positive correlation with NO_3~- -N,and negative correlation with NH_4~+ -N. ③ Both the GWP and GHGI in NM and NMW treatments were significant lower than that of N treatment. However,the crop yields of NM and MMW treatments were significantly increased by 24.6%,36.7% than that of N treatment,respectively. Therefore,the result of this study showed that the application of manure and supplementary irrigation increased crop yields and mitigated greenhouse gas simultaneously.