The impacts of climate change are becoming more and more remarkable. So adaptation to climate change has gradually turned into a global hotpot. Northeast China is an important base of grain production, the impact of climate change on which will directly cause fluctuations of the grain production in China. From the perspective of adaptation to climate change, the key challenges to agriculture due to climate change are analyzed. According to the analysis, four key problems are discussed, which are the increasing heat resources, the rising frequency and intensity of drought and flood disasters, the declining extreme events of low temperature and chilling, and significantly increasing plant diseases and insect pests damage. In view of the above influencing key issues, the adaptation technologies are classified into six categories, namely capital construction of farmland, selection and breeding of anti adversity varieties, tillage and cultivation of crops to cope with disasters, adjustment of planting structure, pest control, and agricultural insurance. In this paper, the key technologies of adaptation to climate change in Northeast China are identified and optimized. They and assorted technologies are assembled and integrated to form a framework of technology system adaptive to climate change. This paper may provide some theoretical guidance and technical support to the adaptation work in different regions and sectors of China to speed up the activities of adaptation to climate change.