To detailed analyze the climate change process in the Hengduan Mountains region (HDMR), spatiotemporal variation of temperature and precipitation were analyzed based on the temperature and precipitation data at 90 meteorological stations in this region from 1961 to 2011,by the linear regression method,the Mann- Kendall nonparametric statistical test and the inverse distance weighted interpolation. The results indicated that the annual mean temperature in the HDMR exhibited significantly increasing trends of 0.16 ℃ /10 a during 1961 2011,while the annual precipitation showed a nonsignificant decreasing trend at a rate of - 11.41 mm/10 a. It implied that the HDMR tended to be much warm and dry. From the spatial distribution of the variation trends of temperature and precipitation,the warming trend of the north was fiercer than that of the south,the west was more intense than the east; and the trend of decreasing precipitation showed that the south was more intense than the north. At the seasonal scale,the temperature increased by 0.09,0. 14,0. 16 and 0.27 ℃ /10 a in spring,summer, autumn,and winter,respectively. Precipitation decreased by - 7.76,- 8.49 and - 2.07 mm/10 a in summer, autumn,and winter,respectively,and increased by 7.34 mm/10 a in spring. At the monthly scale,all twelve monthly mean temperatures exhibited an increasing trend,and the precipitation showed increasing trends from January to May and decreasing trends from June to December. In addition,causes of climate changes were also analyzed. This study can be helpful for deeper understanding of the variabilities in temperature and precipitation in response to climate change,and will provide supports for the water resource management in the HDMR.