The variability of eco-hydrological condition caused by climate change and human activities exerted a significant detrimental influence on water and ecological security in watershed region and national scale. The eco-hydrological model is an important and efficient tool for revealing interactive mechanism between ecological processes and hydrological processes. This paper reviews concept, connotation, construction methodologies and classification as well as domestic and international development of eco-hydrological models, then focuses on the key fields in the studies: ecological regulation and water resources management in wetlands, wetlands restoration and conservation and adaptive water resources management for watershed scale as well as evaluation of eco-hydrological variability under the condition of climate change and corresponding mitigation measures. Considering the problems and weakness in studies, we proposed the development trends of future research and key problems to be solved in wetland eco-hydrological models.