In order to explore the future change trend and spatial pattern of extreme climate in Guizhou Province, this paper predicted daily precipitation, daily maximum temperature and daily minimum temperature from 2011 to 2050 by using the method of NCC/GU-WG Version 2.0 model of weather generator in China and analyzed spatial and temporal variations of extreme climate indices from 2011 to 2050 in Guizhou Province by the way of trend analysis and the software of ArcGIS. The results show that extreme climate indices including TXx, TNn,TX90p and WSDI will increase 0.1℃,0.03℃,0.23 d and 0.4 d per decade, respectively, while extreme climate indices including TXlOp and CSDI will decrease 0.1 d and 0.26 d per decade, respectively, from 2011 to 2050; extreme climate indices including R5D,R95T, SDⅡ and CDD will increase 1.02 mm, 1.31 mm, 5.63 mm, 0.01 mm/d and 0.05 d per decade,respectively, while extreme climate index including CWD will decrease 0.11 d per decade from 2011 to 2050. There were spatial heterogeneities for extreme climate indices and their change trends. Climate warming and terrain are dominant factors affecting variation of extreme climate indices in Guizhou Province.