The fragile ecological regions of plateau have zoom function on global change. Using the remote sensing data and meteorological data with long time series to explore the response of Tibetan Plateau to global climate change is of great significance. Variation trend of NDVI and response to climate change in 4 000 m altitude region of Tibetan Plateau were analyzed by means of maximum value composite,correlation analysis and linear regression and using 19822012 global inventory modeling and mapping studies normalized difference vegetation index and meteorological data contemporary with GIMMS NDVI. The results show that: (1) Tibetan Plateau has remarkable response to global change, annual precipitation and temperature show the significant growth (p<0.05),the annual change rate of NDVI is positive and vegetation coverage shows growth trend over the past 31 years,suggesting that vegetation in Tibetan Plateau has been growing better; (2) NDVI of Tibetan Plateau is not significantly associated with precipitation and temperature,the effect of temperature on NDVI exceeds precipitation in the regions with high altitudes,and the effect of precipitation on NDVI shows hysteresis with 3 years; (3) the terrain has the significant influence on NDVI depending on altitudes and distributions of NDVI contour lines in different regions of Tibetan Plateau,and NDVI in regions with higher altitude is little.