Field investigation, systemi cally collecting lake surface water and glacier melt water of East Hoh Xil have been accomplished in the March 2016. We found that the content of ions in Duoxiu Lake and Yanhu Lake is plentiful, the order of main cations is Na~+ > Mg~(2+) > K~+ > Ca~(2+), the order of main anions is Cl~- > SO_4~(2-) > HCO_3~- > CO_3~(2-). The glacier melt water is fresh water which has low ionic content. According to Kurnakov-Valyashko classification the Duoxiu Lake water belongs to magnesium sulfate subtype while the Yanhu Lake belongs to sodium sulfate subtype. Li-Mg-B has a positive correlation in Duoxiu Lake and Yanhu Lake, suggesting that the material sources,migration conditions and enrichment environment of Li are similar to characteristics of B and Mg in this area. Due to the climate warming,a large amount of melting glacier which has a total salinity (72.6 mg /L and 297.4 mg /L) drains into the Yanhu Lake,meanwhile,Zonag Lake and Kusai Lake outburst to the Yanhu Lake, the area of the Yanhu Lake has been enlarged 5 times comparing with that in 1997,and the total salinity of the lake has been reduced by about 10 times; the degree of total salinity of Duoxiu Lake changes little. The Duoxiu Lake has a high content of Li~+,B_2O_3,Mg,a high degree of mineralization and close the Qinghai-Tibet Highway,which has a good potential utilization value of the resources.