Regional-scale normalized difference vegetation index (NDVI) derived from satellite remote sensing observations and gridded climate data were used to study the seasonal responses and underlying mechanisms of vegetation growth over Tibetan Plateau to Pacific Decadal Oscillation (PDO) at period of 1982-2015,by performing Spearman correlation analysis and enhanced multivariate regression model: structural equation model (SEM). The results showed that there was significant negative correlation between PDO index and mean growing-season (April - October) NDVI over Tibetan Plateau; however,marked seasonal divergence in the relationship between PDO and vegetation growth existed among different seasons. It characterized with stronger negative correlation between PDO and NDVI in autumn than in summer,and winter PDO had significant effect on consequent summer vegetation growth. Additionally,it showed great divergence in control processes of PDO on vegetation growth among different seasons,with significant control of PDO on both temperature and precipitation in summer,and significant control of PDO on temperature only in autumn.