Based on time-series remote sensing imagery (MODIS NDVI, Landsat) and meteorological observation data,this study analyzed spatio-temporal trends of vegetation coverage and their responses to climate change and human activities in the Danjiangkou Reservoir Region between 2000 and 2015 with the application of trend analyses,partial correlation analyses and transfer matrixes of land use. The results showed as follows: 1) There was an increasing trend of annual average vegetation coverage in the Danjiangkou Reservoir Region in the past 16 years,with a growth rate of 4.73% /10 a (p < 0.001). 2) 40.94% of the area increased significantly, which were mainly distributed in hilly lands and alluvial plains around the reservoir; 10.04% of the area showed significant decreasing results,which were primarily located in the northwest of Funiu Mountains and surrounding regions of built-up areas; 49.02% of the area had nonsignificant changes. 3) Vegetation coverage in the Danjiangkou Reservoir Region was not notably affected by climate change,but was greatly influenced by human activities. Shrub-grassland or farmland transformed into forestland was the main reason for the overall increasing trend of vegetation coverage in the reservoir region. Moreover,farmland converted into water body or built-up area was the important factor for the decreasing trend of vegetation coverage in local regions. These changes in land use were mainly driven by afforestation,project of returning farmland to forest,reservoir impounding and construction activities. 4) The implementation of ecological construction projects has played a positive role in the steady increase of vegetation coverage in the Danjiangkou Reservoir Region to a certain extent.