The key control technology of wheat Fusarium head blight(FHB) was established by field experiments under the new normal agricultural conditions of climate change,straw return and the pathogen resistance to carbendazim.The results showed that when the frequency of resistance strains to carbendazim was more than 60%,the control effect of carbendazim was significantly decreased,with the efficacy of less than 60%.The natural disease index of FHB in Huainan and Huaibei was investigated,the disease prevention and control were studied,and the interaction between varieties resistance and fungicides control was also discussed.The results indicate that under the new normal agricultural conditions,the key to the prevention and control of FHB in Jiangsu is to promote the breeding of wheat resistant varieties against FHB,and the non-carbendazim chemical pesticides such as tebuconazole,phenamacril,prothioconazole,etc.are recommended to be used twice at the wheat flowering stage.