Affected by exacerbated climate change and intensified anthropogenic activities, a series of environmental and ecological issues are emerging on the Tibetan Plateau. These seriously undermine the ecological hurdle functions of the Tibetan Plateau, also retard the local productivity development and social living improvement. The Lhasa Alpine Ecology Research Station of the Chinese Academy of Sciences (Lhasa Station) has committed to monitor ecology and environments of the Tibetan Plateau since its establishment. In basic researches, the Lhasa Station conducted a suite of global change studies exploring effects of global changes on ecological hurdle functions of the Tibetan Plateau. The research findings are effectively applied on ecological restoration, and technique development of alpine crop and animal husbandry. In discipline construction, the Lhasa Station carried out multi-disciplinary study and made considerable achievements. Specifically, a series of novelty methods have been developed. Using these methods, the mechanism, pattern, and environmental consequences of alpine ecosystems response to climatic changes, and anthropogenic activities have been revealed. Fueled by the abovementioned basic researches, the Lhasa Station developed core technology and modes for restoring degraded alpine grasslands and alpine crop and animal husbandry, resulting in great achievements. All these achievements have enriched our understanding on impacts of global changes on ecological hurdle function of the Tibetan Plateau, and facilitated technique development and application of alpine crop and animal husbandry. Their integration sets up the stage for the Lhasa Station to be a critical site for research-support and sustainable crop and animal husbandry development demonstration.