Based on MODIS-NDVI data and supported by RS and GIS techniques, the vegetation coverage was estimated from the NDVI dimidiate pixel model in Hubei Province from 2000 to 2015 in this paper. The monadic linear regression trend analysis method and the ordered clustering analysis method were mostly used to analyzing vegetation coverage changes. In addition, The effects of terrain factors such as elevation and slope on vegetation coverage were analyzed by DEM. The results showed that : 1)the vegetation coverage in Hubei was generally low in the west and high in the east and low in the middle and high sides, the topography and land cover types were the important factors that influence the distribution of vegetation coverage in Hubei Province. 2)The vegetation coverage of Hubei Province showed a fluctuated upward trend from 2000 to 2015, but the change was not significant. The basic invariable area accounted for 88.10% of the study area, while the significant increase and significant reduction area accounted for only 1.52% and 1.31% respectively. The Western Hills of Hubei Province were the main improvement areas of vegetation coverage, while the Wuhan megalopolis was the main degraded area. 3)The abrupt change points of vegetation coverage occurred at 700 m and 2800 m in the elevation zones, 14 degrees in the slope zones respectively. The year of 2009 was a significant abrupt change point in vegetation coverage at 100 m and 2 500-2 800 m elevation zones, while the year of 2004 was a significant abrupt change point in vegetation coverage at 300- 400 m and 1 100-2 400 m elevation zones. The year of 2004 was a significant abrupt change point in vegetation coverage at 2 ° -10 ° and 46 °-52 ° slope zones. The change of vegetation coverage in Hubei Province during 16 years may be the result of the interaction of climate fluctuation and the project of returning farmland to forest, and the implementation of the project of returning farmland to forest was the main factor for the increase of vegetation coverage in this area.