The water resource vulnerability of the Pearl River Delta metropolises under the changing environment is multidimensional,changeable and uncertain,with the impact of multiple interference resulted from climate change and intensive human activities. This paper develops an index of water resource vulnerability evaluation of the Pearl River Delta metropolises based on VSD model including exposure, sensitivity and adaptive capacity. An integrated assessment is conducted on the water resource vulnerability of the Pearl River Delta metropolises in 1985 - 2015. The results show that ( 1) The water resource vulnerability increased in Shenzhen,Dongguan and Zhongshan,stabilized in Guangzhou,Foshan and Zhuhai,and decreased in Zhaoqing,Huizhou and Jiangmen. ( 2) The time trends of sensitivities and adaptive capacities are similar for all cities,but the time trends of exposures vary from each other. On average, the water resource per capita in cities with rising vulnerabilities is 19% of water stress state,under big stress of socioeconomic development. The water resource per capita in cities with steady vulnerabilities is 42% of water stress state,under medium stress of socioeconomic development. The water resource per capita in cities with decreasing vulnerabilities is 1. 8 times water stress state,under the lowest stress of socioeconomic development.