The Asia monsoon and westerly are two most important atmosphere circulations in mid-latitude Asia,which climatically dominate Eastern Asia and Central Asia.The previous study discovered the moisture of these two regions varied out-of-phase on multiple scales,from decades to millennium,in the Holocene.Here we investigated their relationships from millenniums to orbital scales since mid-Pleistocene by reviewed our studies recently.The Tajikistan loess is a high-resolution record which documented the climate change since 1.8 Ma.The DK section (38°23'04"N,69°50'01"E) recorded the climate is humid in the interglacials and arid in the glacials in Central Asia,the pattern of which is similar with Chinese Loess Plateau (CLP) loess record (XF section:35°46'N,107°41 'E).However,by comparison the interglacial climate variation pattern on long time scale,it can be discovered the out-of-phase or anti-phase pattern of climate variations between Central Asia and CLP.The cycle analysis investigation further revealed the weak obliquity cycle and strong precession cycle being recorded by Tajikistan loess contrasting CLP loess.On millenniums scales,the climate variation also exhibited an out-of-phase pattern between Central Asia and CLP during interglacials.The magnetic proxies,combing with OSL dating,from several sections,presented a dry Early Holocene,moderate mid-Holocene,and humid Late Holocene pattern in Central Asia,and a dry Early Holocene,humid mid-Holocene,and dry Late Holocene in CLP.In comparison,the climate change in central Asia lagged about 3 ~5 ka.The similar phenomenon also can be detected in last interglacial.We further compared the climate change during glacials.The last glacial record from DK section presented several obvious millennium climate events which were corresponding with D-O events.They exhibited humid climate during warm stages and arid climate during cold stages,the pattern was same to that in CLP,but the events were more intensive.From loess records,it can be concluded that the climate change between Central Asia and CLP presents an out-of-phase pattern during interglacials from millenniums to orbital scales since mid-Pleistocene,but in-phase during glacials.We had poor understand of the climate evolution forcing mechanism in the region.More climate modeling investigations need to developing in the future.