In order to explore impacts of future climate change on main nutritional ingredient in grains of winter wheat,a six-year manipulation experiment of interactive temperature and CO_2 concentration was conducted using the open top chambers and infrared radiators during entire growth period of winter wheat,two scenarios of temperature increase and CO_2 concentration elevation predicted for the middle and late periods of the 21st century were simulated.The results showed that the protein content in grains of winter wheat slightly increased under combined impact of increased temperature and CO_2 concentration during entire growing season.It is likely that the comprehensive impacts of temperature increase have compensated the negative effect of elevated CO_2 concentration on protein content of wheat.Meanwhile,the starch and fat contents in grains of winter wheat were most likely unaffected by the combined effect.It is expected that climate change will probably not cause the decline of main nutritional quality of winter wheat in northern China.