The adverse effects of air pollution and climate change on human health have already been a major global environmental issue, and the challenges in China are even more severe. In this issue, titled"Air Pollution Climate, Change and Health", we present a series of articles that reviewed and analyzed the impact of air pollution and climate change on human health systematically, and propose recommendations for the next phase of research. Meanwhile, we introduce the latest achievements of the World Health Organization (WHO) in coping with air pollution and health, summarize the first WHO Global Conference on Air Pollution and Health, and provide evidence-based guidelines for control and prevention of climate change and air pollution in China.