The "little ice ages" of Ming and Qing dynasties were anomalies in the history of Chinese climate as various natural disasters occurred frequently. Therefore, we aim to make quantitative and systematical analysis in natural disasters of the coastal regions in Zhejiang province during the two dynasties, through searching and collecting relative historical documents. The results show that the occurrence frequencies of natural disasters and losses in the coastal regions of Zhejiang province had clear variations in the spatial-temporal space, and the characteristics can be summarized in the following:① the occurrence frequency of natural disasters increased over time with small fluctuations, and it reached a peak value in the late Ming and early Qing dynasties. Flood and drought occurred most frequently among all natural disasters including typhoon, flood, drought and tide, and especially flood had higher occurrence than the drought.② As a major contributor to natural disasters in coastal regions of Zhejiang province, typhoon had strong correlations with flood and tide disasters, and its disaster chains then spread widely and cause serious damages. Drought and flood had evident inter- correlation changes in the same direction at the same time scale. The explanation for that is potential fluctuations in subtropical high pressure within the same season.③ The occurrence frequency and losses of natural disasters are related closely with the topographical characteristics. Especially, the disaster-bearing topographical environments such as plain, hilly and low-mountains had significant effect on the spatial distributions of four major natural disasters including flood, drought, typhoon and tide in the coastal regions of Zhejiang province. The northern part of Zhejiang province suffered seriously from the drought and tide disasters whereas the both disasters became weak in the central and southern parts of Zhejiang province. Moreover, the typhoon in the Hangzhou Bay generally occurred in the mouth area rather than its peak area, and the occurrence on the south bank was higher than that on the north bank.④ The tide disaster brought about greatest losses among all the disasters, and it was mainly distributed in the plain of northern Zhejiang and was less distributed in either the mountain areas of southern Zhejiang and plain-hills of southeastern Zhejiang.