Based on the observation data at the involved stations,the seasonal variation characteristics of the temperature and precipitation in the mountain area of main stream of Heihe River (hereinafter referred to as the mountain area of the Heihe River,Gansu of China) during the period from 1960 to 2013 and their regional difference were analyzed. The result shows that all annual and seasonal temperature changing processes in the mountain area of the Heihe River and its every sub-region have being presented the rising trend,which is consistent with the global temperature changing trend,and the rise rates of annual mean temperature in the area is significantly higher than the rise rates of global and China's mean temperature. The rising trends of the interdecadal mean temperature are more significant than that of the annual mean temperature in the area in the past over 50 years. But,there were some difference in the rise rates of the annual and seasonal average temperature and the climate tendency rates decrease gradually from the south to the north in the each sub-region of the mountain area of the Heihe River. Thereinto, the rise rates of winter temperature were largest in the east and west branch sub-region located in higher altitude, and the rise rates of autumn temperature were largest in the main stream sub-region located in lower altitude. The rise rates of spring temperature were smallest in every sub-region. All abrupt changes of annual and seasonal average temperatures in the east and west branch sub-region occurred in the mid and late 1990 s. There were larger difference for the time points of abrupt change of annual and seasonal average temperatures in the main stream region. Precipitation change is more complex than air temperature in the each sub-region of the mountain area of Heihe River. Overall,all changes of precipitation in every sub-region in the mountain area presented an increasing trend,and had some difference in the increasing extent in the annual precipitation in each sub-region. Thereinto, the increased extent of annual precipitation in the east branch sub-region were largest,and that in the main stream region was smallest. Although yearly changes of precipitations the mountain area of Heihe River presented an increasing trend as a whole,the rate of increase of the precipitation in each sub-region in each season has large differences. Thereinto,the increasing in summer and autumn were quite significant,and that of precipitation in spring were significant tend for the changes and winter in every sub-region. Fluctuate of inter-decadal variations of the precipitation in each sub-region in each season were more violent than their yearly variation,and the fluctuation range of precipitation in winter and spring were larger than that in summer and autumn. The increase or decrease of precipitation was not synchronized in each sub-region of mountain area of the Heihe River. All abrupt changes of annual precipitation series in the east and west branch sub-regions occurred in 1974,and there are not obvious abrupt changes in annual precipitation series in the main stream region.