Based on the data from Dashankou and Yanqi hydrometeorological stations in the Kaidu River Basin from 1960 to 2010,this study analyzed the features of the temperature and precipitation changes and the responses of the runoff to the climate change using trend analysis,anomaly analysis,multiple regression and linear fitting.The results showed that the temperature in Kaidu River Basin presented an increasing trend in general in recent fifty years. The temperature increased by 1.08 ℃ at Dashankou station and 1.71 ℃ at Yanqi station. The temperature increased in winter was obvious than the increase in summer at Yanqi station while no obvious seasonal variations at Dashankou station. The annual precipitation fluctuations were significant at both stations. The precipitation presented a significant increase at Dashankou station and achieved the fifty-year peak value in 1998. Both temperature and precipitation affected the runoff of Kaidu River. The correlation of the runoff with the temperature and the precipitation was obvious at the upper of the Dashankou station but not the part of the river in Yanqi County. In general,runoff variation had positive correlations with the temperature and the precipitation.