Based on snow product (MOD10A2),temperature,precipitation data from 2000 to 2012 and DEM data, using spatial analysis technology and statistical method,this paper analyzes snow line variation trend and its relationship with climate change in the middle of Qilian Mountains,Nothwest China. The result shows that: 1) The average elevation values of snow line fluctuated upward trend from 2000 to 2012 in the middle of Qilian Mountains, and the average decline rate is 42.3 m/(10 a). The snow line average height value is above 4 600 m and snow line average height value is 4 673 m in recent 10 years. 2) Both the average elevation values of each aspect snow line and average annual increase rate have obviously consistent characteristics in study area,namely the sunny slope > the southern and northern slope > cloudy slope. 3) The temperature in the warm season and total rainfall in the 68 month of 20002012 are the important factors to influence the Qilian Mountains snowline changes, the temperature in the warm season is the main factor to induce the snowline. If cumulative rainfall remain stable in the 6 8 month, the temperature in the warm season increasing (decreasing) 1℃ will result in snow line altitude rising(falling) 58 m in the middle of Qilian Mountains.