Analyzing 707 snow disaster records from 75 counties in Xinjiang region from 1952 to 2013, by means of grey association degree model, the region can be divided into extra-heavy disaster area, heavy disaster area, normal disaster area and less disaster area. Climate trend coefficient and five-order function were used to analyze the long-term variation tendency of livestock mortality in various disaster areas. It was found by Morlet Wavelet analysis that the disaster oscillation cycle had generally a long cycle of about 23 years, a medium cycle of 14~17 years and a small cycle of about 10 years, in addition to a mini fluctuation of 5~7 years, with different harmful intensities and durations, in Xinjiang region as a whole and various disaster areas. Tendency analysis showed that in Xinjiang region as a whole and especially in extra-heavy disaster areas there was a decreasing tendency of livestock mortality in a long time span, but in heavy disaster areas and normal disaster areas there was a slightly increasing tendency of livestock mortality in a long time span. Analysis shows that the long-term change in livestock mortality in extra-heavy disaster areas determines the long-term change in livestock mortality in Xinjiang region; in a long-term, the livestock amount killed by snow disasters is decreasing at a rate of 0.4%; in extra-heavy disaster areas the amount is 98.6% of that in last year. Due to the planned implementation of herdsmen settlement program on a large scale since 1980 in Xinjiang region, the capacity of animal husbandry of the region against natural disasters has been improved greatly; in addition, winter and spring temperature rising nowadays, livestock mortality is going to decrease greatly everywhere. However, because of difference in start time of implementing herdsmen settlement program in different pasturing areas, the peak time of livestock mortality differs in different snow disaster areas.