Snow is an important part of the Earth's surface with high reflectivity and low thermal conductivity which can affect earth's energy and radiation balance. By using the methods of remote sensing and GIS, a wide range of snow cover information is obtained. The spatial distribution characteristics and variation of snow cover are revealed, which can be provided to relevant departments of disaster prevention and mitigation. Based on the MOD10A2 data and records from 48 meteorological observatories of temperature, precipitation, humidity, air pressure and sunshine time from 2003 to 2012 in Sichuan Province, the spatial and temporal variation characteristics of snow cover and their relation with the climate factors in the province in recent 10 years were analyzed. The analysis results show that the spatial distribution of snow cover in the province is high snow cover rate in the western plateau, less snow cover in the Chengdu plain and even no snow cover in eastern basin. From 2003 through 2012,snow cover area had showed a small fluctuation with a peak in 2008. As a whole, snow cover area has a little shrinking tendency; it is found that snow cover rate has significant relation with temperature and precipitation and insignificant relation with air pressure and sunshine time. It is demonstrated that snow cover change in the province is mainly controlled by temperature rather than by precipitation; the higher the temperature and the more the precipitation,the less the snow cover area.