Selecting the loess profile since Holocene in Huining of Gansu Province,we examined the change of climate and enviroment by analysing magnetic susceptibility and grain size.The results indicateed that the changes of climate were partitioned 5 phases since Holocene:13.312.1 kaB.P.(The period of late pleistocene to Holocene), 12.111.3 kaB.P.(the Younger Dryas event),11.38.9 kaB.P.(The fluctuation characteristics of climatic change in temperature),8.94.6 kaB.P.(A period of warming),Since 4.6KaB.P.(Modern climate period).Compared with climate change of the global and the edge area of East Asia monsoon in the same time,we found the good supportive relationship between climate change in Huining region and loess in this region,suggesting that it has a good sensitivity towards the Holocene climate change.