Although a majority of biologists are convinced that a mass extinction is underway on earth today, the human history with direct observatory data is too short to predict its future trends. At least five mass extinctions occurred during the Phanerozoic Eon, causing the rapid extinction of at least 75% of existing marine species; they also seriously affected species diversity on land once the terrestrial ecosystem developed. The causes and consequences of these mass extinctions have become the most useful analogs for understanding whether the current global ecosystem is experiencing an extinction event. Previous multidisciplinary studies of the extinction patterns of fossil groups and concurrent environmental changes of the five mass extinctions during the past 500 million years (occurring in the end-Ordovician,Late Devonian Frasnian-Famennian, end-Permian, end-Triassic, and end-Cretaceous) suggested that no catastrophic event wiped out all organisms on earth. However, all five mass extinctions were associated with serious environmental deterioration and major paleoclimatic changes. The end-Ordovician mass extinction, occurring 445.2-443.8 million years ago, consists of two phases separated by an interval dominated by the cold Hirnantia fauna. The wax and wane of glaciation and associated widespread anoxia were the major causes of the two phases of the end-Ordovician mass extinctions. The Late Devonian mass extinction consists of a few different events from the Givetian to the Devonian-Carboniferous boundary, of which the most important is the Kellwasser event around the Frasnian-Famennian boundary. This extinction most seriously affected the coral and stro- matoporoid reefs, and caused the extinction of two brachiopod orders (Pentamerida and Atrypida). As of yet, there is no consensus on the cause of this extinction event. Global cooling related to the widespread development of the terrestrial vegetation ecosystem and marine anoxia are the two most plausible scenarios. Although impact events were reported from a few horizons in the Late Devonian, they cannot account for the multiple phases of the Late Devonian mass extinctions. The end-Permian mass extinction about 252 million years ago has been universally documented as the most serious, which caused the disappearances of about 95% of all marine and 75% of all terrestrial species. Based on the latest high-precision geochronology data from South China, this extinction happened within an interval of less than 61 thousand years. This extinction was associated with a sharp negative excursion of delta~(13)C_(carb). A rapid temperature rise of 6-8 °C also occurred within the extinction interval.