In order to solve the slope failure caused by the freeze-thaw cycles and global temperature rising in permafrost regions, based on the idea of active cooling for permafrost protection, combined with the frame-anchor and heat pipe cooling technology, a new supporting structure applicable to permafrost slope was proposed, which can provide active cooling and anchor retaining functions, and can reduce the frost heaving damage. The technical principle of the new structure was described. The design control indexes of ultimate bearing capacity and heat balance, and the calculation method of thermo-force combined control for the structure were put forward. The structure and the corresponding calculation method were applied to a construction project. The results show that the proposed structure can prevent the degradation of the upper limit of permafrost slope, uplift the limit and improve the stability of permafrost slope. The method can describe accurately the working mechanism of the structure, which provides a theoretical basis for the design of the structure.