Based on future climate data under RCP4.5 scenario generated from the regional climate modeling system (PRECIS), climatic northern boundary of winter wheat would move northward 147.8 km in 2071-2097 and possible planting area would increase by 1.86 *10~5 km~2 relative to 1981-2010. The variations of agro-climatic resources under RCP4.5 scenario in the potential northward region of winter wheat were analyzed based on the nine selected indexes of agro-climatic resources. Results indicated that: (1) compared with the climate baseline (1961-1990), the light resource in potential northward region would decrease; heat resource would significantly increase with an enhanced variability in the last 30 years of the 21st century; precipitation resource shows an overall slight increasing trend but with an greater fluctuation; (2) in the time slice 2030T (20212050), 2050T (20412070), and 2070T (20612090), light resource would decrease more in the northeast of study area, while less in the southwest; heat resource would increase more in northern area than southern part; precipitation resource would increase obviously in northeast of the potential northward region.