Climate change has become a hot issue in the world,which has a profound impact on human survival, economic and social development. This paper is concerned with the spatiotemporal climate change of the western Hexi Region. The spatiotemporal characteristics of temperature,precipitation,relative humidity and wind speed in the western Hexi Region were systematically analyzed by multiple linear regression model,the methods of inverse distance weighted interpolation and Mann-Kendall abrupt change test,based on the data collected from 14 meteorological stations from 1958 to 2013. It aims to reveal the laws of climate change and provide theoretical references for local government making related policies. The results showed that from the time point of view, there is a significant increasing trend in temperature and the inter-annual rate of change is 0.25 ℃·(10a)~(-1). The average temperature of each season shows a same trend and the trend of spring is the most evident. It can be found that the abrupt change of temperature is mainly detected in 1989. From the space point of view,the average temperature is high in midland and low in the north and south. The analysis leaded us to the conclusion that the precipitation is also in an increasing trend and its inter-annual rate of change is 1.30 mm·(10a)~(-1). Concretely, there is a downward trend in spring while there are opposite trends in summer,autumn as well as winter and the change rate of autumn is more obvious than others. From Mann-Kendall abrupt change test of the study area,it is found that there is no significant abrupt change in precipitation. The spatial variation of precipitation is distinct and the precipitation of northwest is low while southeast is high. Temporal analysis revealed that the annual average relative humidity slightly increases in fluctuation from 1958 to 2013. At the same time it decreases in spring and summer while increases in autumn and winter. The relative humidity indicated that there is an ascending tendency from west to east in space. The change of wind speed shows obvious stage. The Data analysis demonstrated that the abrupt change occurred around 1985 and the trend was more evident after 1991. After abrupt change,the mean is 0.56 m·s~(-1) that lower than before the abrupt change. The change trends of the average wind speed in the four seasons are similar to the trend of the annual average wind speed,all of which have gone through the three stages that are rising,falling rapidly and rising slowly. Compared to other seasons,the difference in the mean value of winter is significant higher. The average wind speed has a descending tendency from north to south.