Grassland is an important part of terrestrial ecosystem.To recognize the law of vegetation change has important significance for sustainable development of grassland and restoration of grassland ecosystem. Based on the data of MODIS EVI and meteorological data from 2005to 2014,we used correlation analysis and residual trend method to analyze the law of vegetation change of grassland in growing season,and the influence of climate factor and human activity on the change in ten years in Qinghai Province.The results showed that:(1)in ten years,the growth rate of grassland EVI in growing season was 0.002 3per year in Qinghai Province,it had an fluctuating increasing trend as a whole;among them,the Loess Plateau in the eastern part had a significantly increasing trend,followed by southern Qinghai Plateau Area sub zone and the Qaidam Basin,Qinghai Lake-Qilianshan Mountain had a degradation trend;(2)grassland EVI in growing season in Qinghai Province had a significant relation with temperature and rainfall,had a positive partial correlation with temperature and rainfall as a whole,its spatial differences of were significant,and more closely related to temperature;(3)with respect to the driving factor,Qinghai Lake-Qilianshan Mountain (level three)and southern Qinghai Plateau area sub zone(level four)were mainly driven by temperature;the Loess Plateau in the eastern part(level three and level four)was mainly influenced by rainfall;the Qaidam Basin(level two,level three and level four),Qinghai Lake-Qilian mountain(level one and level four)and southern Qinghai Plateau Area sub zone(level two and level three)were mainly driven by temperature and rainfall;Other areas mainly influenced by non-climate factors;(4)human activity had a positive effect on grassland vegetation growth in Qinghai Province,especially played major role in the construction and destruction of ecosystem in significant change area of grassland vegetation.