In this paper, the fission track method is used to study the uplift and exhumation processes of the Himalayan orogenic belt in the Dinggye area, southern Tibet, and to explore the coupling of internal and external dynamic geological functions to shape the topography. Due to the episodic tectonic activities, the cooling and denudation of the greater Himalayan crystalline complex (GHC) may be mainly controlled by tectonic activities or the external dynamic geological processes. This study uses apatite fission track (AFT) dating of samples from two section crossing the GHC in the Dinggye area, to constrain the timing and rate of Late Cenozoic denudation and further related tectonic and topographic information. Fission track thermochronology yields AFT ages between 11 Ma and 2 Ma across two north-south GHC section from 3 800 ~4 500 m. Combined with regional thermochronologies, the AFT ages suggest three episodes of cooling and exhumation of the GHC. Different cooling and denudation stages have different driving forces. In the Late Miocene, to 11 Ma, regional uplift and denudation are mainly driven by tectonic activities. During 7 ~3 Ma, the tectonic activities tends to be calm, and the slow cooling and denudation are closely related to the erosion of the river in the region. The rapid cooling and denudation stage since the Late Miocene, the external dynamics have been enhanced since 3 Ma by accelerated fluvial incision. The regional transition from tectonic to climatic exhumation of the Dinggye Himalaya may probably imply that the Himalaya had accomplished a significant elevation before Late Miocene, and further drove a significant change in local and even global climate, which in turn established the base for climate exhumation of the Himalaya since 3 Ma.