In order to explore the change of the total area of lakes in the Qinghai0-Tibet Plateau,in this research RS and GIS techniques were used to extract the data of the lakes with areas larger than 1 km~2 in the Qinghai-Tibet Plateau from 1960s to 2015,and the dynamic changes of the lake areas over the past 50 years were analyzed. Combined with the relevant meteorological data,it concluded the main meteorological factors affecting the changes of lake areas through the analysis of relevance and regression. The results showed that: (1) in the overall process of warming and humidification of the Qinghai-Xizang Plateau,the total area of lakes greater than 1 km~2 showed a trend of increase-decrease-accelerate. From 1960 s to 2015,the total area had increased by 9138.60 km~2 with a growth rate of 23.90%. (2) The total area of lakes with areas between 100 ~ 500 km~2 accounted for the largest proportion in all lakes in the Qinghai-Tibet Plateau. The total area of lakes at different area level generally showed an upward trend. (3) Lakes within the altitude range of 4500 ~ 5000 m in the Tibetan Plateau occupied the biggest total area,whereas the lakes within the altitude range of 4500 ~ 5000 m and those below 3000 m sea level presented relatively drastic changes in areas,showing an increasing trend with fluctuation. The lakes within the remaining altitude ranges generally remained stable. (4) The total area of the lakes in the western and northern Tibetan Plateau showed an overall growth trend,but in the eastern and southern regions it remained basically stable,and the changes in the entire area of the lakes in the Qinghai-Tibet Plateau revealed a spatial expansion trend. (5) The annual mean temperature,annual precipitation and annual evaporation had a significant correlation with the lake areas. There was a significant correlation between the lake areas and annual average temperature in the border area of the study area. The lake areas in the central area of the study area had a significant correlation with the average temperature,annual precipitation,and annual evaporation. The areas of the lakes in the northeastern part of the study area and part of the central and western regions were significantly correlated with the annual average temperature and annual evaporation. According to the regression analysis on meteorological factors and the total lake area,changes in annual average temperature and annual evaporation were responsible for the changes in the total area of lakes in the Tibetan Plateau. This study fills the research gap on the dynamic changes of lake areas in the Tibetan Plateau from perspective of long time series and multi-scale,and the lake data obtained in this study can provide reference to other researchers.