South China,part of Eastern Tethys,developed a huge carbonate platform in the Permian. During the Maokouin Subepoch of the Middle Permian,the carbonate platform experienced a transition from its prosperity to shrink. The southern Guizhou was located at the southern margin of the carbonate platform. It is a good area for discussing the controlling factors of platform evolution by analysis of stratigraphic structure and its variation. In this study,we selected the typical Nashui and Moyang sections of Luodian,southern Guizhou and studied on their carbonate factory by analyzing rock types and skeletal association statistics. As a result,15 rock types,5 sedimentary facies and 6 skeletal associations are recognized by field and indoor research. The carbonate factory features of the skeletal associations were also rebuilt. The results show that a distinct transition from tropical,shallow and warm water factory to tropical,deep and cool water factory occurred starting from the late Kuhfengian in the southern Guizhou,manifested as the beginning occurrence of deep water sediments in the upper Kuhfengian Stage. This transition was widespread from the Kuhfengian to the early Lengwuan in South China,manifested as the shrink of the carbonate platform and the drowning of the platform margin. The late Kuhfengian of the Middle Permian to the Wuchiapingian of the Late Permian was a significant turning point of global geological history where the photosynthetic organisms suffered heavy losses and the marine ecological environment deteriorated sharply. The drastic change of the carbonate factory was related to the inhibition or destruction of the shallow tropical carbonate factory.