DOI: 10.1016/j.envpol.2020.114158
论文题名: The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
作者: Amereh F. ; Babaei M. ; Eslami A. ; Fazelipour S. ; Rafiee M.
刊名: Environmental Pollution
ISSN: 2697491
出版年: 2020
卷: 261 语种: 英语
英文关键词: Bioaccumulation
; Endocrine disruption
; Gene expression
; Histology
; Nanoplastics
; Rat
; Reproductive toxicity
Scopus关键词: Bioaccumulation
; Biochemistry
; Elastomers
; Endocrine disrupters
; Fluorescence imaging
; Gene expression
; Health risks
; Histology
; Inverse problems
; Polymerase chain reaction
; Rating
; Tissue
; Toxicity
; Endocrine disruption
; Follicle stimulating hormone
; Global public health
; Luteinizing hormones
; Molecular signatures
; Nanoplastics
; Reproductive toxicities
; Serum concentration
; Risk perception
; biological marker
; DNA
; follitropin
; gonadorelin
; luteinizing hormone
; microplastic
; nanoplastic
; polystyrene
; testosterone
; bioaccumulation
; endocrine disruptor
; gene expression
; histology
; nanomaterial
; plastic
; pollution exposure
; public health
; reproductive biology
; risk assessment
; rodent
; toxicity
; animal tissue
; Article
; chromatin structure
; controlled study
; DAZL gene
; DNA damage
; endocrine disease
; exposure
; fluorescence imaging
; FSH gene
; gene
; gene expression
; hypothalamus hypophysis gonad system
; LH gene
; male
; nonhuman
; particle size
; PLZF gene
; public health
; rat
; real time polymerase chain reaction
; reproductive toxicity
; sperm
; sperm quality
; spermatogenesis
; testis
; Wistar rat
; Animalia
; Rattus
英文摘要: Humans are potentially exposed to nano(micro)plastics, however their interaction with tissues and cells in humans remains largely unknown. This premise is particularly notable with nano-sized plastic particulates, a potentially most pernicious form of plastic pollution. In this study, even in a hypothetical scenario in terms of dose (1, 3, 6 and 10 mg/kg-day) and exposure time (five weeks), the potential endocrine disturbances with particular reference to reproductive toxicity of polystyrene nanoplastics (PS NPs, average size = 38.92 nm) was studied in male rats considering biomarkers of semen quality, changes in hormonal milieu and molecular signatures of endocrine disruption. Sperm DNA integrity and its chromatin structure were also analyzed. There observed significant inverse associations between exposure to PS NPs and serum concentrations of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Tissue and cell impairments were also noticed even at the lowest tested dosage, though the severity of lesions followed a clear dose-response pattern. DNA damage as well as alterations in sperm morphology and viability were evident, again proportionally with the amount of exposure dosage. RT-qPCR data were in accordance with the results of physio-histological alterations and fluorescence imaging, as significant down-regulation of PLZF, DAZL, FSH and LH gene expressions were noticed in the testis of exposed animals, suggesting that exposure interferes with spermatogenesis and also with HPT-axis. However, among those with highest exposure dosage, expressions of FSH and LH were significantly increased. ABP modulation further revealed evidence of a nonlinear dose response. The association between PS NPs exposure and GnRH was indeed in an unexpected positive direction, though these end-points were less sensitive at higher doses. Although additional evidence is warranted, the present work provides new insights into the possible risks of plastic nanoparticles exposure in humans, especially since the problem is growing and will persist for a long time. © 2020 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/158129
Appears in Collections: 气候变化与战略
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作者单位: Environmental and Occupational Hazards Control Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Clinical Sciences, Faculty of Veterinary Sciences, Bu-Ali Sina University Hamedan, Iran; Department of Anatomy, Faculty of Tehran Medical Science Islamic Azad University, Tehran, Iran
Recommended Citation:
Amereh F.,Babaei M.,Eslami A.,et al. The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge[J]. Environmental Pollution,2020-01-01,261