DOI: 10.1016/j.envint.2020.105488
论文题名: An open source physiologically based kinetic model for the chicken (Gallus gallus domesticus): Calibration and validation for the prediction residues in tissues and eggs
作者: Lautz L.S. ; Nebbia C. ; Hoeks S. ; Oldenkamp R. ; Hendriks A.J. ; Ragas A.M.J. ; Dorne J.L.C.M.
刊名: Environment International
ISSN: 1604120
出版年: 2020
卷: 136 语种: 英语
英文关键词: Chicken
; Global sensitivity analysis
; In vitro to in vivo extrapolation
; Physiologically based kinetic model
; Risk assessment
Scopus关键词: Animals
; Biochemistry
; Forecasting
; Health risks
; Histology
; Kinetic parameters
; Kinetic theory
; Physiology
; Risk assessment
; Sensitivity analysis
; Tissue
; Veterinary medicine
; Calibration and validations
; Chicken
; Environmental contaminant
; Global sensitivity analysis
; In-vivo
; Kinetic modeling
; Lipophilic compounds
; Sensitive parameter
; Physiological models
; monensin
; calibration
; dose-response relationship
; egg
; model validation
; poultry
; prediction
; risk assessment
; sensitivity analysis
; anatomical concepts
; animal health
; animal tissue
; Article
; calibration
; chicken
; concentration (parameter)
; egg
; hydrophilicity
; in vitro study
; in vivo study
; kinetics
; lipophilicity
; mathematical parameters
; nonhuman
; physiological process
; physiologically based kinetic model
; prediction
; priority journal
; quantitative analysis
; risk assessment
; sensitivity analysis
; structure analysis
; validation study
; Animalia
; Gallus gallus
英文摘要: Xenobiotics from anthropogenic and natural origin enter animal feed and human food as regulated compounds, environmental contaminants or as part of components of the diet. After dietary exposure, a chemical is absorbed and distributed systematically to a range of organs and tissues, metabolised, and excreted. Physiologically based kinetic (PBK) models have been developed to estimate internal concentrations from external doses. In this study, a generic multi-compartment PBK model was developed for chicken. The PBK model was implemented for seven compounds (with log Kow range −1.37–6.2) to quantitatively link external dose and internal dose for risk assessment of chemicals. Global sensitivity analysis was performed for a hydrophilic and a lipophilic compound to identify the most sensitive parameters in the PBK model. Model predictions were compared to measured data according to dataset-specific exposure scenarios. Globally, 71% of the model predictions were within a 3-fold change of the measured data for chicken and only 7% of the PBK predictions were outside a 10-fold change. While most model input parameters still rely on in vivo experiments, in vitro data were also used as model input to predict internal concentration of the coccidiostat monensin. Future developments of generic PBK models in chicken and other species of relevance to animal health risk assessment are discussed. © 2020 The Authors Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/158971
Appears in Collections: 气候变化与战略
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作者单位: Department of Environmental Science, Radboud University Nijmegen, Houtlaan 4, XZ Nijmegen, 6525, Netherlands; Department of Veterinary Sciences, University of Torino, Largo P. Braccini 2, Grugliasco, 10095, Italy; Department of Science, Faculty of Management, Science &Technology, Open University, AT Heerlen, 6419, Netherlands; European Food Safety Authority, Via Carlo Magno 1A, Parma, 43126, Italy
Recommended Citation:
Lautz L.S.,Nebbia C.,Hoeks S.,et al. An open source physiologically based kinetic model for the chicken (Gallus gallus domesticus): Calibration and validation for the prediction residues in tissues and eggs[J]. Environment International,2020-01-01,136