globalchange  > 气候变化与战略
DOI: 10.1073/pnas.1702274114
论文题名:
Nonenzymatic gluconeogenesis-like formation of fructose 1;6-bisphosphate in ice
作者: Messner C.B.; Driscoll P.C.; Piedrafita G.; De Volder M.F.L.; Ralser M.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2017
卷: 114, 期:28
起始页码: 7403
结束页码: 7407
语种: 英语
英文关键词: Evolution ; Gluconeogenesis ; Metabolism ; Nonenzymatic reactions ; Origin of metabolism
Scopus关键词: fructose 1,6 bisphosphate ; ice ; amino acid ; fructose bisphosphate ; fructose bisphosphate aldolase ; fructose-1,6-diphosphate ; glucose ; sugar phosphate ; addition reaction ; aldol reaction ; Article ; biosynthesis ; carbon bond ; catalysis ; chemical bond ; controlled study ; gluconeogenesis ; glycolysis ; nonenzymatic gluconeogenesis ; pH ; priority journal ; reaction analysis ; temperature sensitivity ; chemistry ; metabolism ; nuclear magnetic resonance spectroscopy ; pentose phosphate cycle ; phosphorylation ; temperature ; time factor ; Amino Acids ; Fructose-Bisphosphate Aldolase ; Fructosediphosphates ; Gluconeogenesis ; Glucose ; Glycolysis ; Hydrogen-Ion Concentration ; Ice ; Magnetic Resonance Spectroscopy ; Pentose Phosphate Pathway ; Phosphorylation ; Sugar Phosphates ; Temperature ; Time Factors
英文摘要: The evolutionary origins of metabolism, in particular the emergence of the sugar phosphates that constitute glycolysis, the pentose phosphate pathway, and the RNA and DNA backbone, are largely unknown. In cells, a major source of glucose and the large sugar phosphates is gluconeogenesis. This ancient anabolic pathway (re-)builds carbon bonds as cleaved in glycolysis in an aldol condensation of the unstable catabolites glyceraldehyde 3-phosphate and dihydroxyacetone phosphate, forming the much more stable fructose 1,6-bisphosphate. We here report the discovery of a nonenzymatic counterpart to this reaction. The in-ice nonenzymatic aldol addition leads to the continuous accumulation of fructose 1,6-bisphosphate in a permanently frozen solution as followed over months. Moreover, the in-ice reaction is accelerated by simple amino acids, in particular glycine and lysine. Revealing that gluconeogenesis may be of nonenzymatic origin, our results shed light on how glucose anabolism could have emerged in early life forms. Furthermore, the amino acid acceleration of a key cellular anabolic reaction may indicate a link between prebiotic chemistry and the nature of the first metabolic enzymes. © 2017 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/162191
Appears in Collections:气候变化与战略

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作者单位: Messner, C.B., Molecular Biology of Metabolism Laboratory, Francis Crick Institute, London, NW1 1AT, United Kingdom, Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB2 1GA, United Kingdom; Driscoll, P.C., Metabolomics Science Technology Platform, Francis Crick Institute, London, NW1 1AT, United Kingdom; Piedrafita, G., Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB2 1GA, United Kingdom, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, United Kingdom; De Volder, M.F.L., Department of Engineering, Institute for Manufacturing, University of Cambridge, Cambridge, CB3 0FS, United Kingdom; Ralser, M., Molecular Biology of Metabolism Laboratory, Francis Crick Institute, London, NW1 1AT, United Kingdom, Department of Biochemistry, Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB2 1GA, United Kingdom

Recommended Citation:
Messner C.B.,Driscoll P.C.,Piedrafita G.,et al. Nonenzymatic gluconeogenesis-like formation of fructose 1;6-bisphosphate in ice[J]. Proceedings of the National Academy of Sciences of the United States of America,2017-01-01,114(28)
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