globalchange  > 气候变化与战略
DOI: 10.1073/pnas.2002783117
论文题名:
The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus
作者: Mercier R.; Bautista S.; Delannoy M.; Gibert M.; Guiseppi A.; Herrou J.; Mauriello E.M.F.; Mignot T.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期:45
起始页码: 28366
结束页码: 28373
语种: 英语
英文关键词: Type IV pilus | cell motility | small GTPase | Myxococcus xanthus
英文摘要: Type IV pili (Tfp) are highly conserved macromolecular structures that fulfill diverse cellular functions, such as adhesion to host cells, the import of extracellular DNA, kin recognition, and cell motility (twitching). Outstandingly, twitching motility enables a poorly understood process by which highly coordinated groups of hundreds of cells move in cooperative manner, providing a basis for multicellular behaviors, such as biofilm formation. In the social bacteria Myxococcus xanthus, we know that twitching motility is under the dependence of the small GTPase MglA, but the underlying molecular mechanisms remain elusive. Here we show that MglA complexed to GTP recruits a newly characterized Tfp regulator, termed SgmX, to activate Tfp machines at the bacterial cell pole. This mechanism also ensures spatial regulation of Tfp, explaining how MglA switching provokes directional reversals. This discovery paves the way to elucidate how polar Tfp machines are regulated to coordinate multicellular movements, a conserved feature in twitching bacteria. © 2020 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163368
Appears in Collections:气候变化与战略

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作者单位: Mercier, R., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Bautista, S., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Delannoy, M., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Gibert, M., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Guiseppi, A., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Herrou, J., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Mauriello, E.M.F., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Mignot, T., Aix-Marseille Université-CNRS (UMR7283), Laboratoire de Chimie Bactérienne, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France

Recommended Citation:
Mercier R.,Bautista S.,Delannoy M.,et al. The polar Ras-like GTPase MglA activates type IV pilus via SgmX to enable twitching motility in Myxococcus xanthus[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(45)
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