globalchange  > 气候变化与战略
DOI: 10.1073/pnas.2006620117
论文题名:
Rocks in the auxin stream: Wound-induced auxin accumulation and ERF115 expression synergistically drive stem cell regeneration
作者: Canher B.; Heyman J.; Savina M.; Devendran A.; Eekhout T.; Vercauteren I.; Prinsen E.; Matosevich R.; Xu J.; Mironova V.; de Veylder L.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期:28
起始页码: 16667
结束页码: 16677
语种: 英语
英文关键词: Arabidopsis ; Auxin ; ERF115 ; Regeneration ; Stem cells
Scopus关键词: adenosine diphosphate ribosylation factor 5 ; auxin ; transcription factor ; transcription factor ERF115 ; unclassified drug ; Arabidopsis protein ; ERF115 protein, Arabidopsis ; indoleacetic acid derivative ; phytohormone ; transcription factor ; Article ; cell activity ; cell death ; cell division ; cell regeneration ; computer model ; controlled study ; endoderm ; endodermis ; histogenesis ; live cell imaging ; nonhuman ; organogenesis ; priority journal ; protein expression ; protein transport ; stem cell ; Arabidopsis ; cell self-renewal ; cytology ; gene expression regulation ; genetics ; metabolism ; physiology ; plant epidermis ; regeneration ; Arabidopsis ; Arabidopsis Proteins ; Cell Division ; Cell Self Renewal ; Gene Expression Regulation, Plant ; Indoleacetic Acids ; Plant Epidermis ; Plant Growth Regulators ; Regeneration ; Transcription Factors
英文摘要: Plants are known for their outstanding capacity to recover from various wounds and injuries. However, it remains largely unknown how plants sense diverse forms of injury and canalize existing developmental processes into the execution of a correct regenerative response. Auxin, a cardinal plant hormone with morphogen-like properties, has been previously implicated in the recovery from diverse types of wounding and organ loss. Here, through a combination of cellular imaging and in silico modeling, we demonstrate that vascular stem cell death obstructs the polar auxin flux, much alike rocks in a stream, and causes it to accumulate in the endodermis. This in turn grants the endodermal cells the capacity to undergo periclinal cell division to repopulate the vascular stem cell pool. Replenishment of the vasculature by the endodermis depends on the transcription factor ERF115, a wound-inducible regulator of stem cell division. Although not the primary inducer, auxin is required to maintain ERF115 expression. Conversely, ERF115 sensitizes cells to auxin by activating ARF5/MONOPTEROS, an auxin-responsive transcription factor involved in the global auxin response, tissue patterning, and organ formation. Together, the wound-induced auxin accumulation and ERF115 expression grant the endodermal cells stem cell activity. Our work provides a mechanistic model for wound-induced stem cell regeneration in which ERF115 acts as a wound-inducible stem cell organizer that interprets wound-induced auxin maxima. © 2020 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163433
Appears in Collections:气候变化与战略

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作者单位: Canher, B., Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, B-9052, Belgium, Center for Plant Systems Biology, VIB, Ghent, B-9052, Belgium; Heyman, J., Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, B-9052, Belgium, Center for Plant Systems Biology, VIB, Ghent, B-9052, Belgium; Savina, M., Department for Systems Biology, Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russian Federation, LCT & EB, Novosibirsk State University, Novosibirsk, 630090, Russian Federation; Devendran, A., Department of Biological Sciences, Centre for BioImaging Sciences, National University of Singapore, Singapore, 117543, Singapore; Eekhout, T., Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, B-9052, Belgium, Center for Plant Systems Biology, VIB, Ghent, B-9052, Belgium; Vercauteren, I., Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, B-9052, Belgium, Center for Plant Systems Biology, VIB, Ghent, B-9052, Belgium; Prinsen, E., Integrated Molecular Plant Physiology Research, Department of Biology, University of Antwerp, Antwerp, 2020, Belgium; Matosevich, R., Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, Hebrew University of Jerusalem, Rehovot, 7612001, Israel; Xu, J., Department of Plant Systems Physiology, Institute for Water and Wetland Research, Faculty of Science, Radboud University, Nijmegen, 6525 AJ, Netherlands; Mironova, V., Department for Systems Biology, Institute of Cytology and Genetics SB RAS, Novosibirsk, 630090, Russian Federation, LCT & EB, Novosibirsk State University, Novosibirsk, 630090, Russian Federation; de Veylder, L., Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent, B-9052, Belgium, Center for Plant Systems Biology, VIB, Ghent, B-9052, Belgium

Recommended Citation:
Canher B.,Heyman J.,Savina M.,et al. Rocks in the auxin stream: Wound-induced auxin accumulation and ERF115 expression synergistically drive stem cell regeneration[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(28)
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