globalchange  > 气候变化与战略
DOI: 10.1073/pnas.2001384117
论文题名:
Establishing rod shape from spherical; peptidoglycan-deficient bacterial spores
作者: Zhang H.; Mulholland G.A.; Seef S.; Zhu S.; Zhu S.; Liu J.; Liu J.; Mignot T.; Nan B.
刊名: Proceedings of the National Academy of Sciences of the United States of America
ISSN: 0027-8424
出版年: 2020
卷: 117, 期:25
起始页码: 14444
结束页码: 14452
语种: 英语
英文关键词: Germination ; Gliding motor ; GTPase ; MreB ; Rod system
Scopus关键词: actin ; guanosine triphosphatase ; membrane protein ; molecular motor ; MreB protein ; peptidoglycan ; Rod protein ; unclassified drug ; bacterial protein ; guanosine triphosphatase activating protein ; MglA protein, Myxococcus xanthus ; peptidoglycan ; Article ; bacterial spore ; bacterial structures ; cell interaction ; cytoskeleton ; eukaryotic cell ; Myxococcus xanthus ; nonhuman ; polar body ; polarization ; priority journal ; protein degradation ; protein function ; protein localization ; protein protein interaction ; protein stability ; protein synthesis ; spore germination ; surface property ; translation elongation ; bacterial spore ; cell polarity ; cell wall ; cytology ; electron microscopy ; genetics ; growth, development and aging ; metabolism ; morphogenesis ; ultrastructure ; Bacterial Proteins ; Cell Polarity ; Cell Wall ; GTPase-Activating Proteins ; Microscopy, Electron ; Morphogenesis ; Myxococcus xanthus ; Peptidoglycan ; Spores, Bacterial
英文摘要: Chemical-induced spores of the Gram-negative bacterium Myxococcus xanthus are peptidoglycan (PG)-deficient. It is unclear how these spherical spores germinate into rod-shaped, walled cells without preexisting PG templates. We found that germinating spores first synthesize PG randomly on spherical surfaces. MglB, a GTPase-activating protein, forms a cluster that responds to the status of PG growth and stabilizes at one future cell pole. Following MglB, the Ras family GTPase MglA localizes to the second pole. MglA directs molecular motors to transport the bacterial actin homolog MreB and the Rod PG synthesis complexes away from poles. The Rod system establishes rod shape de novo by elongating PG at nonpolar regions. Thus, similar to eukaryotic cells, the interactions between GTPase, cytoskeletons, and molecular motors initiate spontaneous polarization in bacteria. © 2020 National Academy of Sciences. All rights reserved.
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/163456
Appears in Collections:气候变化与战略

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作者单位: Zhang, H., Department of Biology, Texas A&M University, College Station, TX 77843, United States; Mulholland, G.A., Department of Biology, Texas A&M University, College Station, TX 77843, United States; Seef, S., Laboratoire de Chimie Bactérienne, CNRS-Université Aix Marseille UMR7283, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Zhu, S., Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, United States; Zhu, S., Microbial Sciences Institute, Yale University, West Haven, CT 06516, United States; Liu, J., Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, United States; Liu, J., Microbial Sciences Institute, Yale University, West Haven, CT 06516, United States; Mignot, T., Laboratoire de Chimie Bactérienne, CNRS-Université Aix Marseille UMR7283, Institut de Microbiologie de la Méditerranée, Marseille, 13009, France; Nan, B., Department of Biology, Texas A&M University, College Station, TX 77843, United States

Recommended Citation:
Zhang H.,Mulholland G.A.,Seef S.,et al. Establishing rod shape from spherical; peptidoglycan-deficient bacterial spores[J]. Proceedings of the National Academy of Sciences of the United States of America,2020-01-01,117(25)
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